Archive for January, 2010

How Cocaine Addiction Works

Friday, January 22nd, 2010

What is Cocaine
Cocaine is a stimulant, a psychoactive drug that temporarily increases mental and/or physical functioning. Unlike other stimulants, cocaine is not used as a prescription medicine, but is an illicit drug carefully controlled throughout the world. Cocaine is used primarily recreationally and is a widely abused drug.

Cocaine is highly addictive.

Cocaine was very popular throughout most of the 1980s and 90s, and recent studies suggest that its popularity continues strong. Cocaine, also known as “coke”, “c”, “snow”, “flake” and “blow” among other nicknames, is commonly sold on the streets as a fine white powder.

Crack”, on the other hand, is freebase cocaine—a water-insoluble cocaine base. Crack is processed to be smokeable. It is the crackling noises of smoking the drug that has given it its name.

In 2007, there were approximately 2.1 million cocaine users in the US alone, 610,000 of who were current crack users. Eighteen to 25 year olds represent the highest number of current users.

Cocaine Addiction & Other Dangers
Repeated cocaine use can result in addiction. New research into cocaine addiction in the brain is uncovering why. According to the National Institute on Drug Abuse (NIDA), in 2007 close to 1.6 million Americans could be classified as addicted to or abusing cocaine, according to the general diagnostic guidelines.

Cocaine is a very dangerous drug, especially when over- or misused. A 2005 study reported that almost 450,000 of the 1,450,000 visits to emergency rooms across the US were due to cocaine use/misuse. This boils down to almost 1 in 3 ER visits involving cocaine.

There is no safe form of cocaine. Nor is there a safe way to use cocaine. Whether by snorting, injecting or smoking cocaine, you are still at risk of imbibing toxic amounts of the drug. Too much cocaine can result in acute cardiovascular or cerebrovascular emergencies, seizures, and sudden death.

How Cocaine Works in the Brain
Cocaine causes pleasurable effects by stimulating the pleasure and reward centers of the brain. Cocaine stimulates the central nervous system, causing increased levels of dopamine in the reward center. Dopamine is the neurotransmitter associated with pleasure and movement. Normally, certain brain cells, called neurons, use dopamine to communicate amongst each other. In this process, dopamine is released in the brain in response to a pleasure signal. The dopamine-releasing cell recycles the neurotransmitter, shutting off the communication between the neurons.

However, cocaine prevents the dopamine recycling process, resulting in a build up of dopamine in the brain. This causes a never-ending chatter between the neurons—the euphoric high.

Repeated long-term cocaine use causes changes to the brain’s functioning leading to addiction.

How Cocaine Addiction Works
The risks for cocaine addiction are high. New research suggests that prolonged use of cocaine changes a genetic expression, or the behaviour of the gene, in the brain resulting in the prevention of specific enzymes from shutting genes off in the pleasure circuits of the brain. This causes heightened cravings for the drug, and thus drug-seeking behaviours.

As well, with continued use, the brain builds a tolerance for the drug. Continued and prolonged exposure to the drug causes the brain to adapt so that the reward pathways become less sensitive to both natural reinforcements as well as cocaine itself. This decreased sensitivity is a result of decreased amounts of dopamine receptors in the brain, and is also the root of the drug addiction.

Furthermore, the risks of relapse are high with cocaine, as the drug will have a strong hold on the addicted brain even after long periods of sobriety. Research has shown that physical cues, or triggers, cause visceral memories of the using experience that result in intense cravings and even relapse.


Cocaine Addiction Treatment
A Cocaine Addiction Treatment Program is vitally important to a successful recovery from addiction. Rarely does going it alone or going cold turkey work. Addiction is a complicated process with deep roots. Addiction recovery requires support, therapy, and a retraining of the brain.

We believe in an all-encompassing approach to cocaine and all drug addiction treatments. Our Cocaine Addiction Treatment Program treats more than the physical addiction, healing the underlying issues at play. We work together with each of our clients to design an addiction treatment program that works for each individual.

With our different therapies, clients learn to take personal responsibility for their decisions, good and bad, to recognize addiction triggers, and to cope with life’s stresses in a healthy and productive fashion.

Heritage Home also has several non-traditional therapies available, from native healing circles, to laughter therapy, and creative art therapies. Through these classes, clients learn about themselves in new situations, how to interact with others sober, and how to have fun without cocaine.

For more information on cocaine and cocaine addiction:
Heritage Home Drug Rehab Center
Cocaine Addiction Vaccine Research
National Institute on Drug Abuse (NIDA) Cocaine Research Report
National Institute on Drug Abuse (NIDA) Cocaine InfoFacts
Centre for Addiction & Mental Health (CAMH) Cocaine Information

Cocaine Addiction: Gene Alterations From Prolonged Cocaine Use

Monday, January 18th, 2010

US Researchers at NIDA report having identified a key brain mechanism, better explaining how and why cocaine addiction occurs.

Announced last week, January 7th 2009, government scientists at the National Institute on Drug Abuse (NIDA) said that the new discoveries about the root of cocaine addiction could lead to the development of new drug treatments.

In experiments with mice, scientists showed how cocaine affects the epigenetic process histone methylation. Prolonged cocaine use, they found, can cause permanent changes to the way certain genes turn on and off.

Epigenetic is a process that influences a gene’s expression or appearance without changing the underlying DNA sequence, causing the gene to behave, or express, itself differently.

Histone methylation is the modification of certain amino acids in a histone protein, or the protein around which a DNA strand wind, which essentially turns the DNA off.

Cocaine in the brain prevents the enzyme from shutting off genes in the pleasure circuits of the brain, heightening cravings for more cocaine.

Furthermore, scientists were able to reverse the effects by increasing the activity of that particular gene, completely reversing the effects of chronic cocaine use. As well, scientists reported that it is likely that this be the same process for other addictions, including alcohol addiction, thereby potentially leading to new, more effective, addiction treatments.

“This fundamental discovery advances our understanding of how cocaine addiction works,” Dr. Nora D. Volkow, director of NIDA, said via press release. “Although more research will be required, these findings have identified a key new player in the molecular cascade triggered by repeated cocaine exposure, and thus a potential novel target for the development of addiction medications.”

The findings also help to explain addiction’s long-term cravings and relapse despite periods of total abstinence.

Source: Business Week & Ottawa Citizen

New Cocaine Addiction Treatment on the Horizon: A Bacterial Enzyme

Wednesday, January 6th, 2010

Researchers in the UK have identified a bacterial enzyme that, they say, breaks cocaine down in the body, effectively reducing the drug’s addictiveness and may help fight both cocaine addiction and overdose.

The naturally occurring bacterial enzyme, Cocaine esterase or CocE, essentially breaks cocaine molecules down in the body, reducing its physical addictiveness and eventually lead to a new way to treat cocaine addiction, as well as help reduce cocaine overdose.

CocE, researchers found, is only active in the body for a rather short period of time. However, they have also found a more stable version in a double mutant bacterial version, DM CocE.

In their clinical trial, published in the Journal of Pharmacology and Experimental Therapeutics, researchers from The Scripps Research Institute trained rats to self-administer cocaine. By pressing a button, cocaine would be released to the rats, mimicking human drug-seeking behaviour common to all addictions.

Once given the double mutant bacterial enzyme, the rats pressed the cocaine-administering button far less, suggesting that the enzyme successfully broke the cocaine down and rendered it far less physically addictive.

Lead researcher told reporters that although the enzyme is not a fail-safe cure for “determined users”, it could nonetheless prove to be a new effective therapeutic approach.

As with all medical interventions to treat addiction, this new treatment should be used in conjunction with a therapeutic drug addiction treatment program.

However, unlike others, it seems at first to have far less harmful side effects and be less addictive in the long term, and could very well prove to be an exciting development in the treatment of cocaine addiction.

Source: The Telegraph

Alcohol and Marijuana Use Genetically Linked

Monday, January 4th, 2010

New twin study out of the US suggests that the same gene that leads to drinking alcohol may also lead to marijuana use.

Twin studies are used to better understand the genetic influence of behaviours. In such studies, scientists compare the results from identical twin sets, who have identical genetics, with the results from fraternal twin sets, who only share some genes.

The new study looked at 2,761 sets of identical and fraternal twins, as well as 736 non-twin individuals, from 24 to 36 years of age. All subjects were interviewed about their alcohol and marijuana use.

Although researchers found little overlap between the environmental factors that influence use, they found significant overlap in the genetic factors that influence.

In previous twin studies, about 50 to 60 percent of the variance in alcohol dependence could be explained by genetic factors. Studies also previously suggested that genetics played a major role in marijuana and other drug addictions.

However, this new study found that over 60 percent of the variance in alcohol and marijuana use, and marijuana dependence, was linked to genetic factors, supporting the theory that common genes play a role in all addiction & substance abuse.

The results are to be published in Alcoholism: Clinical and Experimental Research March 2010.

Source: WebMD

Happy New Year

Friday, January 1st, 2010